expression and distribution of calcium-binding protein s100p in human placenta during pregnancy

Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy

Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy

BACKGROUND S100P is a member of the S100 family of calcium-binding proteins, and it participates in pathophysiological events, such as tumor growth and invasion. Based on the striking similarities between trophoblast cells and tumor cells with regard to proliferative and invasive properties, we raised the question of whether and how S100P expresses in trophoblast cells during development. This ...

The calcium-binding protein S100P in normal and malignant human tissues

BACKGROUND S100P is a Ca2+ binding protein overexpressed in a variety of cancers, and thus, has been considered a potential tumor biomarker. Very little has been studied about its normal expression and functions. METHODS We examined S100P expression in normal human tissues by quantitative reverse transcription polymerase chain reaction and immunohistochemistry. S100P protein expression was al...

Chondroitin sulfate proteoglycan expression and binding of Plasmodium falciparum-infected erythrocytes in the human placenta during pregnancy.

A characteristic feature of malaria during pregnancy is the sequestration of Plasmodium falciparum-infected red blood cells (IRBCs) in the intervillous spaces of the placenta. We have recently shown that unusually low-sulfated chondroitin sulfate proteoglycans (CSPGs) present in the intervillous spaces mediate the adherence of IRBCs in the placenta. In areas of endemicity, the prevalence of P. ...

Ca2+-binding protein of the human placenta

The Ca2+-binding protein (HCaBP) of the human placenta was studied with respect to its biochemical properties, tissue and cellular distribution, and possible involvement in placental Ca2+ transport. Optimal Ca2+ binding by the HCaBP occurs at pH7-8 and in I00mM-Na+ and 3mM-Ca2+. The HCaBP possesses at least 10 Ca2+-binding sites with a Kd of 5 x 10-6M ([Ca2+]). Highly specific rabbit-derived an...

The effect of lansoprazole administration during pregnancy on the placenta

Introduction: Lansoprazole is one of the proton pump inhibitor drugs widely used in the treatment of gastro-duodenal ulcers and disorders. However, there is not enough data about unexplored adverse effects of lansoprazole on the integrity of the placental barrier. Therefore, the present study was conducted to determine whether placental structure could be affected by lansoprazole administrati...